国外文献 > 1.轴承 > 3. 材料与制造 > 材料性能
关键词搜索：
| 标 题： |
AM to produce load-bearing prostheses: a viable technological perspective for now, in a near future, or never?
AM制造承重假体：目前、近未来还是永远无法实现的可行技术视角？ |
| 作 者： |
Elisabetta M. Zanetti
Gionata Fragomeni
Michela Sanguedolce
Giulia Pascoletti
Luigi De Napoli
Luigino Filice
Gerardo Catapano |
| 关键词： |
3D printing [3D打印]
Additive manufacturing [ 增材制造]
Artificial organs [ 人工器官]
Prostheses [ 假体]
Surgical guides [ 手术指南]
Wear [ 穿戴]
Fatigue [ 疲劳]
Corrosion [ 腐蚀]
Surface [ 表面]
Strength [ 力量]
Clinical [ 临床] |
| 出版年： |
2022 |
| 文集名： |
5th CIRP International Conference on BioManufacturing (BioM 2022)
第五届国际生物制造大会（BioM 2022） |
| 会议名： |
5th CIRP International Conference on BioManufacturing (BioM 2022)
第五届国际生物制造大会（BioM 2022） |
| 届 次： |
5th |
| 摘 要： |
Additive Manufacturing technologies have opened new perspectives for the realization of tissue and organs substitutes. The main advantages come from the possibility of using the same technology to produce artificial or biological substitutes in a wide range of outer shapes and inner reticular architectures, which may pave the way to their use to produce personalized substitutes. Additive manufacturing technologies are based on layer-by-layer material fusion and deposition. As such, they have intrinsic limitations which may hinder the possibility to produce substitutes that meet the requirements for safe clinical use. As an example, discontinuities between layers may make the outer surface of a substitute significantly uneven, rough, and may even weaken the substitute mechanical properties in such an aggressive environment as the human body. Moreover, repeated thermal cycles (fusion and solidification) drastically limit the choice of materials which can be used. Finally, the outcome of the production technology is affected by many variables that it is not trivial to control to deliver the necessary quality and repeatability of the production process for medical applications. Indeed, the surface roughness of an implantable prosthesis or organ substitute is key to modulate cell adhesion and the susceptibility to chemical attack by body fluids. Structural strength is a mandatory requirement for load-bearing prostheses (e.g., orthopedic and dental prostheses). Materials for biomedical applications must not only be 3D printable, but also biocompatible and/or possibly have to promote cells growth and to prevent inflammatory reactions. The performance of artificial, bio artificial and tissue-engineered organs needs also to be certified and guaranteed, a rather difficult task to define for devices which may be unique, being tailored on the specific needs of the patient. In this paper, it will be discussed whether this technology is sufficiently mature to replace more traditional techniques or, alternatively, whether it should be limited to a restricted range of emergency applications until the existing relevant technological gaps are filled.
增材制造技术为组织和器官替代物的实现开辟了新的前景。其主要优势在于能够利用同一技术，生产出具有多种外部形状和内部网状结构的人工或生物替代物，这有望推动个性化替代物的开发。增材制造技术基于逐层材料熔融与沉积，因此存在固有局限性，可能制约其生产出符合安全临床使用要求的替代物。例如，各层之间的不连续性可能导致替代物外表面显著不平整、粗糙，甚至在人体这种严苛环境中削弱其机械性能。此外，反复的热循环（熔化与凝固）极大地限制了可选用的材料种类。最后，该制造工艺的最终结果受到诸多变量的影响，而要确保医疗应用中生产过程具备必要的质量与重复性，控制这些变量并非易事。事实上，可植入假体或器官替代物的表面粗糙度对于调控细胞黏附以及机体液体对化学物质的敏感性至关重要。结构强度是承重假体（如骨科和牙科假体）的必要要求。用于生物医学应用的材料不仅必须具备三维打印能力，还应具有生物相容性，甚至可能需要促进细胞生长并防止炎症反应。人工、仿生及组织工程器官的性能也需经过认证和保障，但这一任务对于可能因针对患者特定需求而定制的独特设备而言，界定起来相当困难。本文将探讨该技术是否已足够成熟，足以取代更传统的技术； 或者在现有相关技术差距尚未填补之前，是否应仅限于某些紧急用途范围。 |
| 中文内容为网络AI翻译，专业术语未必准确，仅供参考。 |
京公网安备 11010202009788