| 标 题： |
3D printing of intrauterine device loaded with silver sulfadiazine to the treatment of fungal diseases
载有磺胺嘧啶银的宫内节育器用于治疗真菌性疾病3D打印 |
| 作 者： |
Ferrari, Gustavo
da Silva, Loise Silveira
Batistella, Tauana
Mannes, Sophia
Silveira, Joao Pedro Vaz
Piva, Caio Prange
Kanis, Luiz Alberto
Salmoria, Gean VitorFerrari, Gustavo
da Silva, Loise Silveira
Batistella, Tauana
Mannes, Sophia
Silveira, |
| 关键词： |
Polymers [聚合物]
Ethylene vinyl acetate [醋酸乙烯酯]
Thermoplastic polyurethane [热塑性聚氨酯]
Silver sulfadiazine [磺胺嘧啶银]
Fungal treatment [真菌治疗]
Intrauterine device [宫内节育器]
Drug delivery [药物递送] |
| 出版年： |
2025 |
| 期刊名： |
The International Journal of Advanced Manufacturing Technology
先进制造技术国际杂志 |
| 年卷期： |
|
| 摘 要： |
Women's health is gaining attention with advancements in medical research and technology focused on addressing unique healthcare challenges and improving the overall well-being of women. Therefore, the main goal of the present study is to develop and manufacture drug delivery devices for fungal treatment concerning women's health attention. Ethylene vinyl acetate (EVA) and thermoplastic polyurethane (TPU) were manufactured by hot melt extrusion (HME) and fused-deposition modeling (FDM (TM)). Drug-loaded prototypes were manufactured combining EVA and TPU matrices with silver sulfadiazine (AgSD). EVA and TPU were loaded with 10 and 20% theoretical drug load resulting in desired intrauterine device geometries. The devices' physicochemical, mechanical properties, and in vitro drug release were characterized. Drug release presented a burst release due to surface agglomerates of AgSD and controlled release after this initial behavior. EVA and TPU samples released from 36 to 66 mu g/day. The mechanical properties were minimally affected since flexural modulus was around 1.3 MPa and stress at 5% strain was 4.8 MPa. The HME and FDM printing was successfully used to produce polymeric devices with the incorporation of silver sulfadiazine into the polymeric matrix. The EVA and TPU devices released for 30 days, showing promising results for the local delivery systems.
随着医学研究和技术的进步，女性健康日益受到关注，重点在于应对独特的医疗挑战并提升女性的整体健康水平。因此，本研究的主要目标是开发和制造用于真菌治疗的药物递送装置，以满足女性健康需求。通过热熔挤出（HME）和熔融沉积成型（FDM）技术，制备了乙烯-醋酸乙烯酯（EVA）和热塑性聚氨酯（TPU）。将银磺胺嘧啶（AgSD）与EVA和TPU基质结合，制备了载药原型。EVA和TPU分别加载了10%和20%的理论药物量，从而获得理想的宫内节育器几何结构。对这些装置进行了物理化学性质、机械性能以及体外药物释放性能的表征。结果显示，药物释放呈突发性，主要由AgSD表面团聚所致，随后进入可控释放阶段。EVA和TPU样品的药物释放量为每天36至66微克。机械性能影响较小，弯曲模量约为1.3 MPa，5%应变时的应力为4.8 MPa。成功利用HME和FDM打印技术，将磺胺银掺入聚合物基质中制备了聚合物器件。EVA和TPU器件在30天内释放，显示出局部给药系统方面的良好效果。 |
| 中文内容为网络AI翻译，专业术语未必准确，仅供参考。 |
京公网安备 11010202009788